ea0063oc5.2 | Adrenal 1 | ECE2019
Martinelli Serena
, Riverso Maria
, Mello Tommaso
, De Filpo Giuseppina
, Canu Letizia
, Maggi Mario
, Mannelli Massimo
, Rapizzi Elena
Pheochromocytoma/paraganglioma (Pheo/PGL) are rare neuroendocrine tumors generally benign. About 3040% of Pheo/PGL are due to germ-line mutations in one of the susceptibility genes, including those encoding the succinate dehydrogenase subunits A-D (SDHA-D). Up to 80% of patients affected by SDHB mutated Pheo/PGL develop metastatic disease with no successful cure at present. In this study, we evaluated the different effect of tumor microenvironment on tu...